{"id":4849,"date":"2026-08-03T23:41:22","date_gmt":"2026-08-03T23:41:22","guid":{"rendered":"https:\/\/crosscountrymovingteams.com\/?p=4849"},"modified":"2026-08-03T23:41:22","modified_gmt":"2026-08-03T23:41:22","slug":"exclusive-former-openai-exec-fidji-simo-discusses-her-battle-with-pots-and-her-startups-plans-to-cure-it-with-ai-and-3500-vials-of-blood-so-far","status":"publish","type":"post","link":"https:\/\/crosscountrymovingteams.com\/?p=4849","title":{"rendered":"Exclusive: Former OpenAI exec Fidji Simo discusses her battle with POTS and her startup\u2019s plans to cure it with AI and 3,500 vials of blood (so far)"},"content":{"rendered":"
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\u201cDo people like my cousin have any reason to have hope that AI can actually make a difference for their health?\u201d I asked Simo when I reached out to her after the announcement. I also told her how much I admired her courage to be so open about her condition. That\u2019s not easy for a highly scrutinized public figure. Simo was previously at Meta for a decade, where she oversaw the Facebook app, and then served as CEO of Instacart, which she brought public in 2023, before joining OpenAI in 2025.\u00a0<\/p>\n

Read more Sea\u2019s Maribank wants to export its Singapore digital banking playbook\u2014first stop, the Philippines<\/a><\/p>\n

\u201cYes,\u201d she answered. \u201cI created a company, ChronicleBio, to tackle just that.\u201d\u00a0<\/p>\n

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We hopped on the phone to chat about it in Simo\u2019s first interview since leaving her position as OpenAI\u2019s CEO of AGI deployment, where she reported directly to CEO Sam Altman. While now her main focus is her recovery and a never-ending schedule of medical appointments, she\u2019s also working on growing ChronicleBio as well as continuing to advise OpenAI. She\u2019s still in a Slack channel with the company\u2019s leadership team, where she regularly speaks with Altman, and Greg Brockman, the OpenAI cofounder and president who took over the bulk of Simo\u2019s responsibilities when she departed.\u00a0<\/p>\n

Brockman\u2019s wife, Anna, has POTS in addition to two other chronic diseases. ChronicleBio\u2019s three cofounders\u2014Simo, Rohit Gupta, and Rishi Reddy\u2014also either have chronic diseases themselves, or have a family member with one. These days, Simo says she\u2019s \u201cphysically the worst I\u2019ve ever been.\u201d There is no cure for POTS. It causes dizziness upon standing up, fatigue, brain fog, headaches, and other symptoms, owing to an imbalance in the body\u2019s autonomic nervous system.<\/p>\n

Chronic conditions are \u201cbecoming a real epidemic,\u201d Simo tells me. \u201cWe\u2019re talking about hundreds of billions in lost productivity, and so there\u2019s very big potential in finding drugs for these conditions.\u201d\u00a0<\/p>\n

In its first year as a company, ChronicleBio has performed 890 blood draws from 709 patients in Utah, Arizona, Texas, and India. It has over 3,500 tubes of blood in its \u201cbiobank,\u201d the company tells me. It\u2019s extracted 153 terabytes of data from the blood\u2014that\u2019s three times the 45 terabytes GPT-3.5, a 2022 model from OpenAI, was trained on. The company has raised $15 million to date.\u00a0<\/p>\n

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The next big thing: home blood draws. On Aug. 11, ChronicleBio will launch a sign-up link for mobile phlebotomy trucks to come to the homes of people with certain chronic diseases. Participants will get an in-depth report on their condition, free for the first 250 people. In exchange, they\u2019ll give their biological data to ChronicleBio.<\/p>\n

The goal is to learn more about diseases and improve the success of clinical drug trials, something Simo says would be nearly impossible without AI.<\/p>\n

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The transcript below has been edited for length and clarity.<\/em><\/p>\n

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Yes, so that\u2019s really what ChronicleBio is meant to solve. We have seen a lot of clinical trials fail because the pharmaceutical companies aren\u2019t able to identify which subset of patients [a drug] could work for. So they end up giving the drug to everyone with the same diagnosis. Let\u2019s say it\u2019s POTS. But there could actually be five sub-diseases within POTS, and the drug would work for one of them, but not the other four. So the clinical trial fails when it could have succeeded if we could have identified these people upfront. It seems really simple, but it hasn\u2019t been done for these conditions.<\/p>\n

That\u2019s exactly right. We have already found five sub-diseases where the biology is really different, despite the symptoms being the same. And now that we understand the biology, we can map that to existing drugs that would solve the problem, and so we\u2019re going to start testing these existing drugs on our patient population before the end of the year. Then we would partner with biotech and pharma to develop new drugs, with the goal of having suitable therapeutics for every part of this patient population.<\/p>\n

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The sub-diseases don\u2019t even have names right now. That\u2019s the problem. So, the way the medical system names these syndromes is by their symptoms. In the case of POTS, it\u2019s called Postural Orthostatic Tachycardia Syndrome. It\u2019s basically named after the symptom: Tachycardia means your heart rate goes up when you stand. But for one group of patients the disease might be driven by the immune system. For another, it\u2019s driven by the mitochondria. The underlying biology is very different, and that\u2019s why one drug isn\u2019t going to work across everyone even if the symptoms are the same.<\/p>\n

Yeah, you know, it\u2019s obviously a horrible disease, and I certainly wish I could have dodged it. But at the same time, I think it has given me enormous meaning. The delta between the disability from these diseases and the amount of funding and research being done on them is terrible. If you look at a condition like chronic fatigue syndrome, it is considered the most disabling disease of all diseases. Like, when you look at the disease chart, it\u2019s completely at the bottom, worse than cancer.\u00a0<\/p>\n

And yet, if you look at the amount of funding for this condition, it\u2019s absolutely pathetic for two reasons: One, it primarily affects women, so of course you get less funding. Second, while it completely disables you, it usually doesn\u2019t kill you. And so the combination of these two things has made it that these diseases are really ignored, even though they affect people at the prime of their lives. You usually get affected between 20 and 40 [years old], and you\u2019re completely disabled. You\u2019re taken out of your life entirely, and so it\u2019s a crazy amount of suffering.<\/p>\n

Read more \u2018Japan\u2019s been very good to us, with the exception, of course, of Pearl Harbor\u2019: Trump awkwardly comes to the Yen\u2019s rescue<\/a><\/p>\n

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[Earlier in our conversation, Simo mentioned she was bedridden for five months of her pregnancy, and she developed POTS a few years later.]<\/em><\/p>\n

Yeah, imagine that 24\/7, impossible to move. [Some] patients are fully bedridden in the dark, sensitive to light, sensitive to sound. It\u2019s a really terrible quality of life, and to me, it seems impossible that with the tools we have today, we would continue to conclude that diseases are incurable and that patients should be in a dark room for years. We owe them something better, given the progress that we\u2019re seeing in a lot of disciplines.<\/p>\n

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The complexity of these diseases made it that without AI they were incredibly difficult to solve. Like I said, they\u2019re multisystem, so you need to be looking at the state of the nervous system, the state of the immune system, and how it correlates with your genetics. All of that is a massive data problem that was very hard to get your hands around without AI. And so finally we have AI, and then on top of that, you have the cost of these analyses going down. Doing a genetic analysis years ago was way more costly than it is now. Analyzing 150 terabytes of data would have been either impossible or would have taken years, and now it takes us minutes.\u00a0<\/p>\n

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So that\u2019s what gives me a lot of hope. I\u2019m physically the worst I\u2019ve ever been, but at the same time, we are at a moment in time where we have the best tools we\u2019ve ever had to solve diseases that are considered incurable.<\/p>\n

We\u2019re using a combo of OpenAI and Anthropic models. We\u2019re using anything that\u2019s available that can help.<\/p>\n

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The reason I did ChronicleBio is because I really think that we are missing true biological data to make progress towards discovering drugs. Right now, a lot of the models use a lot of EHR data\u2014medical records. But medical records don\u2019t tell you enough about biology. They\u2019re incredibly noisy. They don\u2019t tell you how the human body works. If you look at LLMs, they work so well because the internet existed, right? You already had all of this language. We are missing the internet of biology.\u00a0<\/p>\n

Right now we\u2019ve acquired all of this data [from blood] by partnering with clinics, but we think it\u2019s really important to get that data from anyone who wants to participate. We\u2019re now in the process of opening up our tests to anyone in the U.S., with mobile phlebotomy coming to their house. That\u2019s going to allow us to have a much larger dataset, but also reach patients that are bedridden, that are in the sickest stages of the disease. And we actually return the data to patients, so that gives them more information about that condition in case that can help direct them towards a particular therapy. So that\u2019s basically what we\u2019re up to.<\/p>\n

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It\u2019s next week [on Aug. 11]. We partnered with mobile phlebotomy companies that collect the blood in a kit. They send that to us. We get it analyzed. It takes a couple weeks because these analyses are very robust. And then we send back a report to the patient about everything we learned, and that data goes into our database. And then over time, if we have more findings about which sub-disease the patient might have or things like that, we continue keeping them posted, and then they can take the test over time, so at multiple points in time, so that we can also see how they evolve. So if they went on a particular drug, did their immune system change? That gives us longitudinal data about the evolution and progression of these diseases.<\/p>\n

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That\u2019s right. The test we do is very focused on these particular complex chronic conditions. So it\u2019s not just the standard blood tests that are common. It\u2019s a really advanced research-grade blood test.<\/p>\n

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We\u2019re making it free for the first 250 patients because we really want to make sure they are getting value out of the report. After that, it\u2019s going to cost $400. We\u2019re doing it at cost, meaning that\u2019s what it costs us, and we\u2019re charging the same for patients. The whole point for us is not to make money. It\u2019s to collect data so we can find cures.<\/p>\n

Thank you for your interest! We\u2019re excited. You know, when I was at OpenAI, I said, \u201cI think if AI accomplishes everything but doesn\u2019t cure disease, that would be a very sad state of affairs.\u201d The real promise of AI has always been to cure disease. I think it would be a tragedy if we had all of these amazing tools in our hands, but weren\u2019t able to turn them into drugs that can save patients\u2019 lives on a time frame that matters.\u00a0<\/p>\n

Read more SoftBank, Hitachi, LG back Zenity\u2019s $125 million round to police AI agents<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Simo is a cofounder of ChronicleBio, which aims to cure complex chronic diseases by analyzing biological data with the latest AI models.<\/p>\n","protected":false},"author":1,"featured_media":4848,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-4849","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-openai"],"yoast_head":"\nExclusive: Former OpenAI exec Fidji Simo discusses her battle with POTS and her startup\u2019s plans to cure it with AI and 3,500 vials of blood (so far) - Cross Country Moving Team<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/crosscountrymovingteams.com\/?p=4849\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exclusive: Former OpenAI exec Fidji Simo discusses her battle with POTS and her startup\u2019s plans to cure it with AI and 3,500 vials of blood (so far) - 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