{"id":5255,"date":"2026-08-14T09:42:54","date_gmt":"2026-08-14T09:42:54","guid":{"rendered":"https:\/\/crosscountrymovingteams.com\/?p=5255"},"modified":"2026-08-14T09:42:54","modified_gmt":"2026-08-14T09:42:54","slug":"the-hidden-risk-of-glp-1-drugs","status":"publish","type":"post","link":"https:\/\/crosscountrymovingteams.com\/?p=5255","title":{"rendered":"The\u00a0hidden\u00a0risk of\u00a0GLP-1\u00a0drugs"},"content":{"rendered":"
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When patients rapidly lose weight, they also tend to lose muscle mass and\u00a0bone\u00a0density, which can increase their risk of fractures and long-term mobility issues. That\u2019s why it\u2019s so important for patients taking\u00a0GLP-1s to work with their doctors \u2014 and pair the medicines with exercise and strength training.<\/p>\n

Read more Buried in OpenAI\u2019s latest research: No correlation between AI use and revenue per employee<\/a><\/p>\n

GLP-1s work by mimicking glucagon-like peptide-1, a hormone in the body that regulates blood sugar, appetite, and digestion. Essentially, the drugs make patients feel full longer, which reduces food intake and predictably leads to weight loss. Patients can lose 5%-20% or more of their body weight within a year of therapy, and also see significant improvements in their cardiovascular\u00a0health.<\/p>\n

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But when people shed those pounds, they also tend to lose muscle and\u00a0bone. About 25% of the total weight loss tends to come from a decline in musculoskeletal mass.<\/p>\n

That, in turn, may increase the risk of fractures, especially in older adults. While data on fractures among individuals using\u00a0GLP-1s is still limited, one study found that older adults with type 2 diabetes using\u00a0GLP-1s had an 11% increased risk of fractures. \u00a0<\/p>\n

Older women and those in perimenopause may be particularly vulnerable. Women already lose muscle mass and\u00a0bone\u00a0density as their estrogen levels fall during menopause \u2014 they can lose 10-20% of their peak\u00a0bone\u00a0mineral density during the menopause transition. Concomitant\u00a0GLP-1\u00a0use can exacerbate those losses.<\/p>\n

This evidence does not mean that older patients cannot use or benefit from these medications; however, they do\u00a0need\u00a0to be aware of these secondary effects \u2014 and work with their doctors to mitigate them.<\/p>\n

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Initially, patients should have a thorough conversation with their physicians about the benefits and\u00a0risks\u00a0of\u00a0GLP-1s \u2014 especially if patients are broadly healthy and are interested in the drugs for mostly cosmetic reasons.<\/p>\n

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Patients should also consult their doctors to develop a treatment plan that prioritizes exercise and strength training. That combination treatment \u2014\u00a0GLP-1s paired with exercise \u2014 can simultaneously promote weight loss while preserving\u00a0bone\u00a0and muscle\u00a0health. Strength training, in particular, helps stimulate\u00a0bone\u00a0growth and may boost\u00a0bone\u00a0mineral density.<\/p>\n

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Patients should also ensure proper nutrition, following diets high in protein, calcium, vitamin D, and magnesium to promote muscle and\u00a0bone\u00a0health.<\/p>\n

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At times,\u00a0GLP-1s can seem like miracle drugs. Though they were originally developed to help patients combat diabetes and lose weight, emerging research suggests they also improve cardiovascular\u00a0health\u00a0and may have potential beneficial effects on kidney disorders, osteoarthritis, and even addiction.<\/p>\n

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Given how powerful they are, it\u2019s easy to see why 12% of Americans have already taken one, and why that share is increasing by the day.<\/p>\n

But losing weight is supposed to improve our\u00a0health, not put it at risk. Patients\u00a0need\u00a0to familiarize themselves with the drawbacks, not just the benefits, of these medicines \u2014 and collaborate with their doctors to safeguard their long-term muscle strength and\u00a0bone\u00a0health\u00a0as much as possible, rather than purely shrinking their waistlines.<\/p>\n

The opinions expressed in Fortune.com commentary pieces are solely the views of their authors and do not necessarily reflect the opinions and beliefs of <\/em>Fortune.<\/em><\/p>\n

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There’s something the tens of\u00a0millions\u00a0of Americans who are currently on\u00a0GLP-1\u00a0medications, or thinking of starting them,\u00a0need\u00a0to\u00a0know.<\/p>\n","protected":false},"author":1,"featured_media":5254,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[313],"tags":[],"class_list":["post-5255","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-glp-1s"],"yoast_head":"\nThe\u00a0hidden\u00a0risk of\u00a0GLP-1\u00a0drugs - Cross Country Moving Team<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/crosscountrymovingteams.com\/?p=5255\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The\u00a0hidden\u00a0risk of\u00a0GLP-1\u00a0drugs - 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